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Mediso - nanoScan PET/CT

nanoScan PET/CT

Best resolution in the industry with high sensitivity: fully integrated, large FOV small animal PET/CT system for quantitative in vivo imaging with complete animal handling system

The nanoScan PET/CT preclinical in vivo imager offers user-friendly imaging and the broadest range of supported applications in one simple to use, high-end PET/CT system. The nanoScan PET/CT is equipped with an imaging technology that is widely considered to have most advanced PET and CT detector construction, data processing and reconstruction chain in the industry.

The preclinical nanoScan PET/CT ensures achieving the best imaging resolution as well as the highest sensitivity with unmatched image quality in the whole body of the animal.

Looking for exceptional soft-tissue contrast, and anatomical information obtained with non-ionizing radiation in the preclinical imaging field? Read more about our nanoScan PET/MRI.

Summary of Key Benefits

  • Highest resolution PET subsystem with outstanding quantification:
    • ≤ 0.7 mm resolution (measured with Derenzo phantom and reconstructed with Tera-Tomo™ 3D PET engine)
    • Uniform resolution over the entire FOV
    • Quantitative accuracy better than 97%
  • Imaging capability for larger animals, such as monkeys with 16cm gantry bore diameter and 12 cm Transaxial Field of View (TFOV) in both modalities
  • Open tunnel PET/CT construction
    • Tail injection and blood sampling with animal in the axial FOV - ideal for dynamic PET applications
    • Backdoor access to the animal with re-sealable door opening
  • Fully integrated with MultiCell™, the complete small animal environment system to provide vital support functions to lab animals during the whole application process
  • Integrated cardiac and respiratory gating capabilities for both PET and CT
  • Standalone use is possible for each modality
  • Fully compatible with nanoScan® PET/MRI, NanoSPECT/CT® and NanoPET/CT®
  • Compliant with CE, DICOM, CFR 21 industry standards
  • Compact and easy-to-use design

Bone imaging in MouseSelected Features for PET subsystem

  • Superior PET detector characteristics: Physical performance matches animal imaging performance
    • High-density, ultra-small detectors in tight packing with finest LYSO detector elements in the industry with smallest pitch
    • Increased crystal thickness for highest sensitivity
  • Measure even the finest details: Tera-Tomo™ 3D PET reconstruction engine brings PET resolution close to the physical limits with outstanding quantification and better signal recovery and signal-to-noise ratio: 
    • Features Monte Carlo system matrix modeling and Depth of Interaction correction; incorporates attenuation, scatter, positron range, random and dead time corrections.
    • Reconstruction running on multiple GPUs (Graphical Processing Units) delivering shorter computational time
  • Perform Acquisition and Reconstruction simultaneously with the powerful workstations including DICOM server and multi-modality display and analysis suite

420g weight, 7.21MBq/0.2ml, start pi.1h, 30min/ 1FOV, 1:5Selected Features for CT subsystem

The X-ray CT alone is a powerful whole-body preclinical imaging system on its own right. Image the largest variety of species in industry including larger animals or a whole body mouse scan in one bed position. Offering a very large detector surface area and large bore with helical scanning possibility, variable zoom (up to 8) and high power X-ray source (up to 80W).

  • Broadest range of CT applications: Ultrafast and ultralow dose CT with variable zoom up to 7.6x magnification to visualize even the smallest organs or in-vitro samples up to 120mm FOV
    • Perform a whole-body mouse scan in 2 minutes - have the result instantly with 80 micron voxel size
    • Closest source-object distance for in-vivo: extra small objects imaging
  • Tomographic information is ready at the end of scan*: on the fly real time reconstruction is enabled by multi-GPUs (* for general settings)
  • Lower X-ray exposure dose to the animals and faster data acquisition due to stronger X-ray tube, increased detector area, sensitivity and better filtering
  • Fully automated calibration processes
  • Improved safety functions gantry rotation position is stored, X-ray ramp-up and run-up are optimized to ensure prolonged tube lifetime

System Design

  • Spiral mode with extended axial field of view of 30 cm for both modalities

    64 Cu-Cetuximab-Fab whole-body imaging of a NMRI Nu/Nu mouse with FaDu tumor xenograft 48 hours post i.v. injection of 34 MBq labeled Fab. Imaging duration 30 min, imaged actual activity cca. 3 MBq. Two plane sections and a MIP. Besides heterogeneous uptake in the tumor, kidney cortex and liver is visible, too. Image courtesy of Helmholtz-Zentrum Dresden Rossendorf, Germany

  • Accessability to the animal during scanning: Flat front cover with minimized dead area in both axial and transaxial directions
  • Fully automated animal positioning based on CT scout; manual adjustment is also supported
  • System is equipped with remote access possibility for service and remote diagnostics
  • Safety switches are both in the acquisition and control room allowing immediate stop of the examination
  • 17” touchscreen monitor on the gantry which allows the user to control bed movements, gantry rotation, positioning for CT zoom and positioning related calibrations and settings